Effect of antidepressant therapy on blood glucose and blood lipid in patients with unipolar depression / 西安交通大学学报(医学版)

Objective: This study investigated the occurrence and possible causes of metabolic abnormalities in patients with unipolar depression. Methods: We recruited 103 hospitalized patients with unipolar depression and 100 healthy controls. The patient group was treated with antidepressants for 3 weeks. Metabolic indicators (fasting blood glucose, total cholesterol, triglycerides, high-density lipoprotein) were measured before and after treatment. Results: Fasting blood glucose, total cholesterol and high-density lipoprotein were significantly higher in patients with unipolar depression than in healthy controls (P0.05). After treatment with antidepressants, serum fasting blood glucose level was significantly lower than the baseline value (P<0.05). Fasting blood glucose and total cholesterol were significantly higher in patients with recurrent unipolar depression than in the healthy controls (P=0.049, P=0.031). The patients aged above 30 years had significantly higher fasting blood glucose and total cholesterol levels than those aged 30 or younger (P=0.001, P=0.016). Fasting blood glucose level was positively correlated with the number of episodes, and a regression equation could be established as Yfasting blood glucose=0.26xincidence times +4.01. Conclusion: Repeated episodes of depression increase the risk of metabolic problems. Antidepressant treatment helps improve fasting blood glucose. The risk of unilateral depression metabolism may be related to the recurrent disease and has little to do with drug treatment.

Laparoscopic spleen-preserving splenic hilar lymph nodes dissection through retropancreatic and extruded approach in radical gastrectomy for advanced gastric carcinoma / 局解手术学杂志

Objective To investigate the feasibility and safety of laparoscopic spleen-preserving splenic hilar lymph nodes dissection through retropancreatic and extruded approach in radical gastrectomy for proximal gastric carcinoma,and to preliminarily analyzed the anatom-ical features.Methods Adopted a retrospective cohort study.The clinical data of 84 patients with proximal gastric carcinoma who underwent radical resection in our hospital from June 2014 to January 2017 were collected.Among the 84 patients,44 case who underwent spleen extru-ded-retroperitoneal approach were regarded as the observation group,and the other 40 patients underwent conventional left approach were allo-cated into the control group.All the patients underwent laparoscopic D 2 radical total gastrectomy and spleen-preserving N0.10 nodes dissec-tion by the same operation team.The clinical situation of the two groups before operation,after operation and during the follow-up were ob-served.Results All the 84 patients successfully completed the radical gastrectomy without conversion to open surgery.In the observation group and the control group,the volume of intraopertative blood loss were respectively(107.9 ±52.9)mL and(153.1 ±72.2)mL;the opera-tion time were respectively(228.8 ±27.7)min and(244.7 ±31.3)min;the number of dissected N0.10 lymph node were respectively(5.0 ± 2.2)and(2.9 ±1.3).There were statistically significant differences in all the above indexs(P<0.05).In the observation group and the control group,the time for initial out-of-bed activity were respectively(1.6 ±0.4)days and(1.5 ±0.4)days;the time of initial anal exsuffla-tion were respectively(2.9 ±0.8)days and(2.6 ±0.5)days;the duration of hospital stay were respectively(7.5 ±1.4)days and(7.0 ± 1.3)days.Postoperative complications occured 4 cases in the observation group and 5 cases in the control group.There was no statistically significant difference in terms of time for initial out-of-bed activity,time of initial anal exsufflation,duration of hospital stay and postoperative complications(P>0.05).A total of 82 patients were followed up for 6 to 36 months,with a median time of 15.5 months.Conclusion Compared with the conventional left approach,laparoscopic spleen-preserving splenic hilar lymph nodes dissection through retropancreatic and extruded approach is safe and feasible for laparoscopic radical resection of proximal gastric carcinoma.And it can shorten the operation time, reduce the volume of intraopertative blood loss,and increase the clearance of N0.10 lymph nodes.

Optimization for preparation process of fanhuncaoin dry powder for inhalation / 中国药学杂志

OBJECTIVE: To optimize the preparation process conditions of fanhuncaoin dry powder for inhalation by orthogonal design. METHODS: Fanhuncaoin dry powder was prepared by spray-drying method. Following spray-drying, particle size analysis was performed by laser diffraction. Resultant powders were characterized using scanning electron microscopy. The aerosolisation performance was determined using twin-stage liquid impinger. And moisture content was examined by thermogravimetric analysis. The preparation process conditions were optimized with orthogonal design combined with multi-index test. The powder yield, aerodynamic diameter, moisture content and respirable fraction were used as indices for orthogonal design. RESULTS: The results of optimized process parameters were confirmed with atomization pressure of 210 kPa, feed flow rate of 9.1 mL·min-1, aspiration speed of 0.6 m3·min-1 and inlet temperature of 130℃. As a result, 51.19% yield, 2.92 μm aerodynamic diameter, 4.18% moisture content and 54.45% respirable fraction are obtained by the optimal process conditions. CONCLUSION: Orthogonal design combined with multi-index test can be used to optimize the preparation process of fanhuncaoin dry powder for inhalation.

Prognostic Value of Gai's Plaque Score and Agatston Coronary Artery Calcium Score for Functionally Significant Coronary Artery Stenosis / 中华医学杂志(英文版)

<p><b>BACKGROUND</b>The prognostic values of the coronary computed tomography angiography (CCTA) score for predicting future cardiovascular events have been previously demonstrated in numerous studies. However, few studies have used the rich information available from CCTA to detect functionally significant coronary lesions. We sought to compare the prognostic values of Gai's plaque score and the coronary artery calcium score (CACS) of CCTA for predicting functionally significant coronary lesions, using fractional flow reserve (FFR) as the gold standard.</p><p><b>METHODS</b>We retrospectively analyzed 107 visually assessed significant coronary lesions in 88 patients (mean age, 59.6 ± 10.2 years; 76.14% of males) who underwent CCTA, invasive coronary angiography, and invasive FFR measurement. An FFR <0.80 indicated hemodynamically significant coronary stenosis. Lesions were divided into two groups using an FFR cutoff value of 0.80. We compared Gai's plaque scores and CACS between the two groups and evaluated the correlations of these scores with FFR. The statistical methods included unpaired t-test, Mann-Whitney U-test, and Spearman's correlation coefficients.</p><p><b>RESULTS</b>Coronary lesions with FFR <0.80 had higher Gai's scores than those with FFR ≥0.80. Gai's score had the strongest correlation with FFR (r = -0.48, P < 0.01) and had a greater area under the curve = 0.72 (95% confidence interval: 0.61-0.82; P < 0.01) than the CACS of whole arteries and a single artery.</p><p><b>CONCLUSIONS</b>Both CACS in a single artery and Gai's plaque score demonstrated a good capacity to assess functionally significant coronary artery stenosis when compared to the gold standard FFR. However, Gai's plaque score was more predictive of FFR <0.80. Gai's score can be easily calculated in daily clinical practice and could be used when considering revascularization.</p>

Association of ERCC6 gene polymorphisms and DNA damage in lymphocytes among coke oven workers / 中华劳动卫生职业病杂志

<p><b>OBJECTIVE</b>To investigate the association between ERCC6 gene polymorphisms and peripheral blood lymphocyte DNA damage among the workers in coking plant.</p><p><b>METHODS</b>By cluster sampling, 379 coke oven workers having worked for 8 hours were included in the exposure group, 398 coke oven workers having rested for more than 16 hours were included in the recovery group, and 398 workers having never been exposed to polycyclic aromatic hydrocarbons (PAHs) in the same plant were included in the control group. Lymphocytes were separated from their peripheral venous blood, and single cell gel electrophoresis was used to evaluate DNA damage; TaqMan-MGB probes were used to analyze ERCC6 gene polymorphisms. PHASE 2.0.2 genetic analysis software was used to calculate the haplotypes.</p><p><b>RESULTS</b>The Olive tail moment (OTM) of lymphocytes in the exposure group was significantly higher than those in the recovery group and control group (-0.86±0.70 vs -1.14±0.68 and -1.13±0.65, P < 0.05). In the exposure group, for workers ≥37 years old, the OTM of lymphocytes in workers carrying CG+GG genotype at rs3793784 locus of ERCC6 gene was significantly lower than that in workers carrying CC genotype (P < 0.05); the OTM of lymphocytes in workers <37years old carrying CC genotype at rs3793784 locus of ERCC6 gene was significantly lower than that in workers ≥37 years old carrying CC genotype (P < 0.05); the OTMof lymphocytes in workers <37 years old carrying CG+GG genotype at rs3793784 locus of ERCC6 gene was significantly higher than that in workers ≥37 years old carrying CG+GG genotype (P < 0.05). For patients with internal exposure, in the 1-hydroxypyrene >4.36 ümol/L group, the OTM of lymphocytes in workers carrying AG+GG genotype was significantly higher than that in workers carrying AA genotype (P < 0.05).</p><p><b>CONCLUSION</b>Different genotypes of ERCC6 gene rs3793784 in peripheral blood lymphocytes of coke oven workers exposed to PAHs have different functions at different ages, suggesting that genotype may interact with age in population exposed to PAHs.</p>

Benefits of promoting male circumcision among the general population in the high HIV prevalence areas of Guangxi Province / 中华男科学杂志

<p><b>OBJECTIVE</b>To evaluate the effect of promoting male circumcision among the general population in the high HIV prevalence areas of Guangxi Province.</p><p><b>METHODS</b>We interviewed 590 male residents from Hezhou and Qinzhou areas of Guangxi Province and conducted intervention using male circumcision promotion materials and various methods. If the subjects were willing and had no contraindication, they were referred to the appointed hospitals to receive circumcision. We conducted follow-up visits at 6 and 9 months after intervention for the changes in the subjects' knowledge, attitude and practice related to male circumcision.</p><p><b>RESULTS</b>The male circumcision knowledge, willingness and operation rate were significantly improved after intervention (P < 0.05), but with no significant difference between the two follow-up visits (P > 0.05). The number of those who knew that phimosis and redundant prepuce were the reasons for circumcision increased from 66.1% at baseline to 81.9% and 79.8% at the two follow-up visits; those who knew that circumcision could prevent AIDS and sexually transmitted diseases increased from 28.0% to 77.4% and 78.6%; those who knew that surgical complications could be pain, bleeding and infection increased from 29.5%, 19.3% and 39.3% to 72.5%, 58.2% and 59.4% at the first follow-up and 75.0%, 57.0% and 63.0% at the second; those who were willing to receive circumcision increased from 35.3% at baseline to 59.6% and 61.3% at the two follow-up visits; and the rate of surgery increased from zero to 12.7% and 16.1%.</p><p><b>CONCLUSION</b>The promotion of male circumcision among the general population in the high HIV prevalence areas of Guangxi Province significantly improved their knowledge, attitude and practice related to AIDS prevention. And the promotion activities should focus on the publicity of AIDS knowledge, risks of phimosis and redundant prepuce, and safety of circumcision.</p>

Meta-analvsis on the effects of health education towards HIV/AIDS high-risk behavior,knowledge, and related attitude among floating population in China / 中华流行病学杂志

Objective To evaluate the effects of health education on HIV/AIDS high-risk behaviors,knowledge,and attitude among floating population in China.Methods A computerized literature searching was carried out in Chinese Biomedical Database,Chinese National Knowledge Infrastructure,Wan Fang and VIP databases to collect articles published in China between 2005 and 2010.Words as “AIDS”,“ Floating Population”,“ Intervention ”,“ Health Education ”,“ High-risk Behavior” were used.Type of studies would include “self-control intervention studies or studies containing sections of self-control intervention”.Meta-analyses were performed to assess 8 outcomes which targeting on high-risk behavior,knowledge and attitudes of AIDS.RevMan 4.2 software was used to analyze the intervention effects for these indexes.Results After the interventions,the rate on awareness of “Whether condoms can reduce the HIV/AIDS infection risk” increased by 23％ [rate difference (RD) 95％ CI: 0.19,0.27] and “Whether keeping monogamous sexual relationship can reduce the risk of infection” increased by 18％ (RD 95％CI: 0.14,0.23 ).The proportion of “Willing to use condoms in sexual life” increased by 16％ (RD 95％ CI: 0.11,0.22) ; and “The incidence of commercial sex behaviors” reduced by 6％ (RD 95％ CI:-0.11,-0.02).“The Ratio of condom use during commercial sex behaviors” increased by 17％ (RD 95％CI: 0.10,0.23).and “Recent use of condoms during sex” increased by 25％ (RD 95％CI: 0.15,0.35).All the data showed significant differences (P＜0.01),respectively.Conclusion After health education,great improvements were found for HIV-related sexual knowledge,attitudes,and behaviors among the floating population.

Generating a reference interval for fasting serum insulin in healthy nondiabetic adult Chinese men

<p><b>INTRODUCTION</b>Circulating insulin concentrations provide important information for the evaluation of insulin secretion and insulin resistance. Reference intervals are the most widely applied tool for the interpretation of clinical laboratory results. We carried out an analysis of the data available from the Fangchenggang Area Male Health and Examination Survey in order to derive a reference interval for fasting insulin specific to the Chinese population.</p><p><b>METHODS</b>A total of 1,434 fasting serum insulin results were obtained from healthy nondiabetic adult men aged 20-69 years, after taking into consideration the inclusion and exclusion criteria. Serum insulin was measured using electrochemiluminescence immunoassays. Nonparametric statistical methods were used to calculate and analyse the data.</p><p><b>RESULTS</b>The reference interval for fasting serum insulin for Chinese adults was in the range 1.57-16.32 μU/mL (median 5.79 μU/mL). Significant correlations were found between fasting serum insulin and glucose and diastolic blood pressure (p < 0.001). Statistically significant differences were observed in insulin concentration with respect to age and body mass index (BMI; p < 0.001). Younger people had a higher fasting serum insulin concentration. Increased fasting serum insulin was also found to be associated with BMI.</p><p><b>CONCLUSION</b>We established a reference interval for fasting serum insulin in healthy nondiabetic adult Chinese men that is lower than what was previously suggested. BMI and age (but not smoking, alcohol consumption or physical activity) were found to be important factors associated with fasting serum insulin. Our results will help improve the diagnostic interpretation of investigations for metabolic and cardiovascular disorders in a Chinese population.</p>

Value of prospectively electrocardiography-triggered high-pitch computed tomography in the follow-up of patients with previous coronary stent implantation / 中华心血管病杂志

<p><b>OBJECTIVE</b>To explore the value of prospectively ECG-triggered high-pitch spiral mode CT coronary angiography (CTCA) in the follow-up of patients with prior coronary stent implantation.</p><p><b>METHODS</b>According to the different scan modes, ninety-six patients with heart rate below 75 beat per minute, sinus rhythm and weight below 100 kg and previous coronary stent implantation who underwent 128-slice dual-source Flash spiral CT coronary angiography were randomly divided into two groups according to the randomly numbers in the envelopes: group A(the prospective electrocardiography gated group, 50 cases) and group B(the prospectively ECG-triggered high-pitch spiral mode group, 46 cases). The image quality was evaluated with a four-point grading scale (1 = excellent, 2 = good, 3 = poor, 4 = very poor or non-diagnostic). The total effective dose and the total dose length product between the two groups were recorded respectively. The CTCA enhanced effective dose, dose length product, and the CT volume dosage index (CTDIvol) between the two groups were recorded respectively.</p><p><b>RESULTS</b>A total of 157 stents were implanted, there were 78 stents in group A and 79 stents in group B, and the value of the image quality was (1.3 ± 0.6) scores in group A and (1.4 ± 0.6) scores in group B (P > 0.05). The total effective dose [(7.6 ± 1.8) mSv vs. (1.6 ± 0.3) mSv] and dose length product [(545.8 ± 131.5) mGy×cm vs. (111.4 ± 19.8) mGy×cm]of the entire scan process were significantly higher in group A than in group B (all P < 0.01). The CTCA enhanced effective dose [(6.7 ± 1.7) mSv vs. (1.2 ± 0.2) mSv], dose length product [(480.8 ± 121.9) mGy×cm vs. (84.2 ± 17.5) mGy×cm] and the CTDIvol [(35.7 ± 8.6) mGy vs. (4.5 ± 0.9) mGy] of group A were also significantly higher than those in group B (all P < 0.01).</p><p><b>CONCLUSIONS</b>It is clinically feasible to use the dual-source Flash spiral CT coronary angiography for the follow-up of the patients with previous coronary stent implantation. This new process can substantially reduce the radiation dose while preserving good imaging quality.</p>

Acceptability of male circumcision among male miners in Baise of Guangxi / 中国医学科学院学报

<p><b>OBJECTIVE</b>To investigate the acceptability of male circumcision among male miners in Baise, Guangxi, China.</p><p><b>METHODS</b>A questionnaire-based survey on the willingness to be circumcised (WTC) and its influential factors were conducted among Guangxi male miners recruited by random cluster sampling.</p><p><b>RESULTS</b>Of 569 subjects who were surveyed, 143 (25.13%) expressed their willingness to be circumcised. Univariate analysis showed that marital status, education level, and the awareness of the hazards of phimosis and redundant prepuce and reasons for circumcision were significantly different between WTC group and the non-WTC group (all P<0.05). Furthermore, the incidence of phimosis or redundant prepuce also significantly differed between these two groups (P=0.0001). Logistic regression analysis found marital status (OR=0.498ì95%CI=0.272-0.913), history of foreskin disease (OR=8.181, 95%CI=4.252-15.741), and awareness of the risk that a redundant prepuce may cause smegma (OR=1.713ì95%CI=1.090-2.693) were significantly correlated with the male miners WTC.</p><p><b>CONCLUSIONS</b>Male miners in this area have low WTC. Education on the basic knowledge of acquired immunodeficiency syndrome and circumcision may help promote the application of circumcision.</p>

A literature review on the conceptual framework of sub-health / 中国中西医结合杂志

<p><b>OBJECTIVE</b>To further articulate the conceptual framework of sub-health by way of literature review.</p><p><b>METHODS</b>Published papers and relevant literature about sub-health were collected, the representative publishing about theoretical exploration and practical surveys were focused for analyzing and assessing the category of sub-health, investigative objects, assessing tools, conceptual framework, diagnostic criteria and its operability, foundation support, etc.</p><p><b>RESULTS</b>Sub-health conditions were categorized into three kinds in most documents, namely, the somatic, the mental and the social adaptative sub-health, and the relevant symptoms were classified into three levels. However, contents regarding the homogeneous issues, such as meaning and definition of sub-health, its diagnostic criteria and operability, in different documents were discrepant.</p><p><b>CONCLUSION</b>Discrepancy exists between the theoretical and practical studies of sub-health. And detailed description is needed to articulate the problems respectively on specific and non-specific sub-health. The perspicuity of conceptual framework is the basis of sub-health researches. The authors recommended that to form the framework the four-level hierarchic structure should be adopted; in developing the assessing tool for sub-health diagnosis, besides the basic assessment on concrete conditions, the differential evaluation on the belonging of overall manifestations, subjective complain or objective symptom, should also be paid attention to.</p>

Clinical and cranial MRI analysis on five cases of toxic encephalopathy induced by dichloroethane / 中华劳动卫生职业病杂志

<p><b>OBJECTIVE</b>To investigate the clinical features, cranial MRI and treatment of toxic encephalopathy induced by 1, 2-dichloroethane (1, 2-DCE).</p><p><b>METHODS</b>The clinical, MRI features and treatment of 5 patients with toxic encephalopathy induced by 1,2-DCE were observed and analyzed.</p><p><b>RESULTS</b>Five patients all presented with subacute onset with a history of direct exposure to 1,2-DCE. Lumbar cerebrospinal fluid pressures were all increased in 5 patients. All 5 patients had obvious intracranial hypertension. Liver and kidney function had no obvious abnormalities; Cranial MRI showed T1WI low signal and T2WI high signal in bilateral hemispheric white matter, cerebellar dentate nucleus and globus pallidus. After the treatment of dehydrating agent, glucocorticoid and supportive treatment, four patients were clearly improved, and one patient had cerebral hernia formation.</p><p><b>CONCLUSION</b>The main neurological clinical features in patients with 1,2-DEC poisoning is obvious intracranial hypertension. The prognosis is usually good with early and long term use of glucocorticoids and dehydrating agent in poisoning patients.</p>

Spatial distribution of Cd and Cu in soils in Shenyang Zhangshi Irrigation Area (SZIA), China / 浙江大学学报（英文版）（B辑：生物医学和生物技术）

Heavy metal contamination of soils, derived from sewage irrigation, mining and inappropriate utilization of various agrochemicals and pesticides, and so on, has been of wide concern in the last several decades. The Shenyang Zhangshi Irrigation Area (SZIA) in China is a representative area of heavy metal contamination of soils resulting from sewage irrigation for about 30 years. This study investigated the spatial distribution and temporal variation of soil cadmium (Cd) and copper (Cu) contamination in the SZIA. The soil samples were collected from the SZIA in 1990 and 2004; Cd and Cu in soils was analyzed and then the spatial distribution and temporal variation of Cd and Cu in soils were modeled using Kriging methods. The results show that long-term sewage irrigation had caused serious Cd and Cu contamination in soils. The mean and the maximum of soil Cd are markedly higher than the levels in second grade standard soil (LSGSS) in China, and the maximum of soil Cu is close to the LSGSS in China in 2004 and is more than the LSGSS in China in 1990. The contamination magnitude of soil Cd and the soil extent of Cd contamination had evidently increased since sewage irrigation ceased in 1992. The contamination magnitude of soil Cu and the soil extent of Cu contamination had evidently increased in topsoil, but obviously decresed in subsoil. The soil contamination of Cd and Cu was mainly related to Cd and Cu reactivation of contaminated sediments in Shenyang Xi River and the import of Cd and Cu during irrigation. The eluviation of Cd and Cu in contaminated topsoil with rainfall and irrigation water was another factor of temporal-spatial variability of Cd and Cu contamination in soils.

Influences of excision repair cross complementation group 4 genetic variations on DNA damage in lymphocytes among coke oven workers / 中华劳动卫生职业病杂志

<p><b>OBJECTIVE</b>To investigate the relationship between excision repair cross complementation group 4 ERCC4 gene polymorphisms and DNA damage in lymphocytes of coke oven workers and controls.</p><p><b>METHODS</b>Two hundred and forty-six coke oven workers and one hundred and twenty-seven controls were recruited in the study, and peripheral vein blood was drawn after over night fasting. Comet assay was used to evaluate DNA damage, and TaqMan-MGB probes were used to analyze ERCC4 genetic variations including the three Tagged-single nucleotide polymorphisms (Tag SNPs), referred to rs744154, rs3136079 and rs31870 which were picked out from Hapmap database. Then haplotypes were reconstructed by PHASE2.0.2 software.</p><p><b>RESULTS</b>The lymphocytes Olive TM value of coke oven workers was significantly higher than that of controls (1.26+/-1.12 vs 0.52+/-0.97, P<0.01). Among coke oven workers, no significant difference was found between the Olive TM of those with different genotypes or haplotype pairs at ERCC4 gene (P>0.05). However, in the control group, the TG genotype carriers had higher Olive TM than the TT and GG genotype carriers (0.26+/-0.96 vs 0.66+/-0.98 and 0.66+/-0.51, P<0.05), and the CTG/CTG haplotype pairs carriers had the highest Olive TM (0.69+/-1.01), and no CTG haplotype carriers had the lowest Olive TM (0.25+/-0.80), and the difference was borderline (P=0.08).</p><p><b>CONCLUSION</b>The gene polymorphism at ERCC4 gene has no effects on the DNA damage of lymphocytes in coke oven workers, but the TG genotype carriers has lower DNA damage in the control. DNA damage is influenced by the interaction of genetic and environmental factors.</p>

Significant positive correlation of plasma BPDE-albumin adducts to urinary 1-hydroxypyrene in coke oven workers / 生物医学与环境科学（英文）

<p><b>OBJECTIVE</b>To investigate the application of BPDE-albumin adducts as monitoring biomarkers for coke oven workers exposed to polycyclic aromatic hydrocarbons (PAHs) and to explore possible relationship between BPDE-albumin adducts and urinary 1-hydroxypyrene (1-OHP) levels in them.</p><p><b>METHODS</b>Thirty-seven coke oven workers from a coke plant and 47 controls without the occupational exposure to PAHs were recruited in this study. The levels of plasma BPDE-albumin adducts and urinary 1-OHP were analyzed using high performance liquid chromatography.</p><p><b>RESULTS</b>The median levels of BPDE-albumin adducts (42.10 fmol/mg albumin) and urinary 1-OHP (5.46 micromol/mol creatinine) were significantly higher in coke oven workers than in controls (14.16 fmol/mg albumin, 2.96 micromol/mol creatinine, respectively; P<0.01). Multiple logistic regression analysis showed that coke oven workers were at higher risk of having BPDE-albumin adduct levels above 25.30 micromol/mg albumin (OR=1.79, P<0.01) and urinary 1-OHP levels above 4.13 micromol/mol creatinine (OR=2.45, P<0.05). There was a positive correlation between the levels of BPDE-albumin adducts and urinary 1-OHP in all subjects (rs=0.349, P<0.01).</p><p><b>CONCLUSION</b>BPDE-albumin adduct is a useful biomarker for monitoring long-term exposure to PAHs, and plasma BPDE-albumin adducts level is significantly correlated to urinary 1-OHP levels in coke oven workers.</p>

Analysis on TCM syndrome distribution laws in 319 patients with coronary heart disease / 中国中西医结合杂志

<p><b>OBJECTIVE</b>To study TCM syndrome distribution laws in patients with coronary heart diseases (CHD) by epidemiological investigation.</p><p><b>METHODS</b>A clinical survey was carried out in 319 inpatients with CHD, whose diagnosis was confirmed by coronary arteriography, in the authors' hospital from January 2004 to December 2004. The TCM syndrome distribution laws were analyzed, and the relationship of coronary arteriographic picture with TCM syndrome elements, common symptoms, pulse and tongue figures, as well as the correlation between syndrome typing and blood-lipid levels were analyzed, too.</p><p><b>RESULTS</b>Qi deficiency was the most popular syndrome in patients with CHD (87.1%), blood stasis syndrome and phlegm retention syndrome took the second place, accounting for 79.9% and 78.7% respectively. No significant difference was shown in comparison of tongue and pulse figures with the affected branches of coronary artery, the dark-pale tongue with white greasy fur and taut-slippery pulse being the dominance in patients. The blood-lipid levels in patients with various TCM syndrome types were similar, showing insignificant difference.</p><p><b>CONCLUSION</b>The TCM pathogenesis of CHD takes qi deficiency as the core, blood stasis and phlegm retention as the important pathologic products.</p>

Application of non-randomized study in the field of traditional Chinese medicine or integrated traditional Chinese and Western medicine / 中国中西医结合杂志

Non-randomized studies (NRS) have gradually attracted people's attention in the field of clinical medicine. In this paper, the importance of NRS was emphasized on the viewpoints of the coherence of scientific research, the limitation of randomized control trials (RCTs), the immanent characteristics of TCM clinical practice and the actual requirement of complex intervention in clinical practice. And two main points in evaluation and implementation of NRS differed to those in RCTs were put forward, i.e. the first, the full-scale design of the study with the professional characteristics should be described very explicitly, especially the speciality of the objects, intervention elements and indexes for effectiveness evaluation, etc.; the second, the control of bias and evaluation of effectiveness, and their influence on conclusion induction should be fully taken into consideration. At the same time, the key step in improving the quality of NRS of TCM and integrative medicine was preliminary discussed in this paper.

Exploration on establishment and application of soft index survey tools in TCM study / 中国中西医结合杂志

This paper discussed the concept, categorizations, methods and basic principles for establishing of soft index survey tools (SIST) in clinical medicinal field, pointed out the relation between the connatural theoretical and practical mode of TCM and the establishment of SIST having TCM characteristics, and elaborated several key points which should be paid attention to in the establishment of SIST. It was pointed out that there was broad space for application of SIST in TCM study.

Polymorphisms of hsp 60 gene in Chinese Han people / 中华劳动卫生职业病杂志

<p><b>OBJECTIVE</b>To identify the single nucleotide polymorphisms (SNPs) in the regulatory and coding regions of heat shock protein 60 gene and search for its genetic makers in Chinese Han people.</p><p><b>METHODS</b>The 5' flank region, parts of the exons and introns of hsp60 gene were resequenced to identify the SNPs in Chinese Han people, and then the sequenced results to the Japanese, European and African's data in National Center for Biotechnology Information (NCBI) and HapMap databases were compared.</p><p><b>RESULTS</b>One novel SNP was identified in exon 2 resulting in synonymous variant and the G allele frequency was 0.025. There were 11 reported SNPs in the sequenced region. The minor allele frequencies of rs1116734, rs3749095, rs1050347, rs8539 were 0.51, 0.30, 0.29, 0.49. The heterozygosity of the other 7 SNPs was 0. The distributions of rs1116734, rs1050347, rs8539, rs3749095 in Chinese Han people were similar to the Japanese's. The hsp60 rs3749095 which was not found in Japanese people was a high-frequency SNP in Chinese Han people; the distribution of rs8539 in Chinese Han people was quite different from European and African's (P < 0.01).</p><p><b>CONCLUSION</b>The SNPs of hsp60 in Chinese Han people are different from the other peoples. The SNPs of hsp60 gene rs1116734, rs3749095, rs1050347, rs8539 are very common in Chinese Han people and might be used for candidate genetic markers of hsp60 gene.</p>

The influence of occupational exposure and smoking on lung ventilation of coke oven workers / 中华劳动卫生职业病杂志

<p><b>OBJECTIVE</b>To study the influence of occupational exposure and smoking on lung ventilation function of coke oven workers.</p><p><b>METHODS</b>Environmental monitoring was performed on the top, side and bottom of some coke ovens. Lung ventilation function test was performed in 234 coke oven workers.</p><p><b>RESULTS</b>The poison concentration in environment had such tendency as it was the highest on the top, then the side, and the lowest at the bottom. The standardized forced expiratory volume in the 1st second (FEV(1), 90.8% +/- 8.6%) and forced expiratory rate (FEV(1)%, 95.4% +/- 12.4%) of those coke oven workers who smoked were significantly lower than those non-smoking workers (100.9% +/- 14.3%, 108.9% +/- 17.6%); among those smoking workers, the partial correlation coefficients between forced vital capacity (FVC) and benzene soluble, benzopyrene, and smoking index were -0.249, -0.187 and -0.368 respectively; and the coefficients between FEV(1) and the three aspects were -0.255, -0.191 and -0.388; and the coefficients between FEV(1)% and them were -0.131, -0.107 and -0.065. Among those non-smoking workers, the coefficients between benzene solubles and FVC, FEV(1) and FEV(1)% were -0.154, -0.052 and -0.176, and between benzopyrene and them were -0.121, -0.037 and -0.159.</p><p><b>CONCLUSION</b>The lung ventilation function of coke oven workers has certain negative correlation with both occupational exposure and smoking.</p>